Some AD Examples from Graham Robson, Katie Welch, Jonathan Splitlog, Oreta Taylor

Graham Robson Designs

I would suggest you put the large AD on one board and the two smaller ADS on another board.
Make sure the continuity is there throughout all 3 ADS.  Make sure you can read all the type and make sure your client logo is large enough on all 3 ADS (although it can be scaled accordingly to  each composition.)

Katie Welch Designs

Jonathan Splitlog Designs